Transfer Prescriptions

Custom Compounding · HRT

Hormone replacement therapy, compounded for you.

Personalized HRT formulations for women and men experiencing hormonal changes. Our Defiance compounding lab has been formulating prescription hormone preparations for 25+ years — estrogen, progesterone, testosterone, and combinations — in the dose, ratio, and delivery method your provider prescribes.

25+
Years compounding HRT
1998
PCCA member since
6+
Delivery methods we compound
All 3
Locations stock HRT

What HRT Is

Replacing the hormones your body used to make.

Hormone replacement therapy gives your body back the hormones it's no longer producing in the amounts it used to. The goal is generally the same regardless of who you are: bring your hormones into a range that helps you feel more like yourself.

Women in menopause

After menopause, estrogen and progesterone levels drop to a fraction of what they were. HRT may help support symptoms like hot flashes, night sweats, sleep disruption, mood changes, vaginal dryness, and bone health. Most women on HRT use a combination of estrogen and progesterone (progesterone is important if you still have your uterus).

Women in perimenopause

Perimenopause is the years (sometimes a decade) before menopause officially begins, when hormone levels start fluctuating unpredictably. Many perimenopausal women use compounded progesterone, low-dose estrogen, or combination preparations to smooth out the fluctuations — often before menopause symptoms become severe.

Men with low testosterone

Testosterone replacement therapy (TRT) is the men's side of HRT. Common reasons men start TRT include fatigue, low libido, difficulty maintaining muscle mass, mood changes, and reduced cognitive sharpness — all confirmed by lab-verified low testosterone. We compound TRT in multiple delivery methods, often alongside anastrozole or HCG when the protocol calls for it.

Why Compounding Matters

When manufactured HRT isn't the right fit.

Manufactured HRT works well for many patients. But it comes in fixed doses, fixed ratios, and a limited number of delivery methods. Compounding fills the gaps.

Custom doses

Manufactured HRT typically comes in a handful of standard strengths. If your provider wants you on 0.625mg estradiol but the manufactured options jump from 0.5mg to 1mg, compounding makes the exact dose possible. The same goes for progesterone, testosterone, and combination preparations.

More delivery methods

Creams, capsules, troches, pellets, injections, vaginal preparations — your provider picks the method that fits your absorption pattern, lifestyle, and preferences. Some patients absorb hormones better transdermally; others tolerate oral delivery just fine. Compounding gives you and your provider the options.

Combined preparations

Need estradiol + estriol in a specific ratio? A testosterone + anastrozole combination cream? Progesterone in a transdermal rather than a capsule? Compounding lets us combine hormones into a single preparation rather than asking you to manage multiple separate prescriptions.

Adjustments without starting over

If your provider wants to fine-tune your dose mid-cycle based on labs or how you're feeling, we can adjust the formulation without you having to switch products or wait for a new manufactured strength to arrive. The goal is always landing on the right regimen — not whatever's easiest to fill.

Delivery Methods

Six ways your provider can prescribe HRT.

There's no single right way to take HRT — it depends on which hormones you need, how your body absorbs them, and what fits into your daily routine. Here are the most common methods we compound.

Transdermal creams

Applied to the skin — typically the inner arm, thigh, or wrist. Bypasses the liver, which can be a consideration for some patients. The most common delivery method we compound for both women's and men's HRT.

Most common

Capsules

Taken orally, usually once or twice daily. Standard for progesterone (which is commonly prescribed at bedtime for its sleep-supporting properties) and a common option for estradiol and testosterone in some protocols.

Troches

Small lozenges that dissolve between your cheek and gum. Absorbed through the mucous membranes in your mouth, bypassing the digestive tract. Useful for patients who have trouble with capsules or whose providers want a more rapid absorption profile.

Pellets

Small implants placed under the skin (usually in the hip area) by a provider. Release hormones steadily for 3-6 months. Most often used for testosterone and estradiol. We don't place pellets — your provider does — but we work with several area providers who use them.

Provider-administered

Injections

Intramuscular or subcutaneous injection, typically weekly or twice-weekly. Most common for testosterone replacement therapy in men, though some women's protocols also use injectable estradiol. We compound with multiple ester options (cypionate, enanthate, propionate) when prescribed.

Vaginal preparations

Local estrogen for vaginal dryness, irritation, or urinary symptoms — typically estradiol or estriol in cream or suppository form. Treats local symptoms without significantly raising systemic estrogen levels. Often prescribed alongside systemic HRT or as a standalone preparation.

What We Compound

Hormones available at our Defiance lab.

Working from prescriptions written by your provider, we compound the major hormones used in HRT — alone or in combinations — in the delivery method your protocol calls for.

Estrogens

  • Estradiol (E2)The primary estrogen most HRT regimens use
  • Estriol (E3)A weaker estrogen, often used vaginally or in combination preparations
  • Biest (E2 + E3)Combined estradiol + estriol, typically in an 80/20 or 50/50 ratio
  • Triest (E1 + E2 + E3)Estrone + estradiol + estriol combination

Progesterone

  • Bioidentical progesteroneCapsules, transdermal creams, or troches
  • Sustained-release progesteroneFor patients whose providers prefer extended-release formulations

Testosterone

  • Transdermal testosterone creamMen's and women's doses
  • Testosterone capsulesLess common, used in select protocols
  • Injectable testosteroneMultiple esters when prescribed (cypionate, enanthate, propionate)

Adjuncts & combinations

  • DHEAAdrenal hormone precursor, capsule or cream
  • PregnenoloneHormone precursor, capsule or cream
  • AnastrozoleUsed alongside TRT to manage estrogen conversion
  • Combination preparationsEstradiol + testosterone, biest + progesterone, etc.

How It Works

From your provider's office to your front door.

Starting HRT (or transferring an existing prescription) involves a few steps. Here's what to expect.

1

Talk with your provider

HRT requires a prescription, so the first step is a visit with a provider who handles hormone health. We don't prescribe — but we work with providers across the region who do, and we're happy to point you toward options.

2

Get baseline labs

Most providers order baseline hormone labs before starting HRT — typically estradiol, progesterone, testosterone (free and total), FSH, LH, and thyroid markers. Labs help your provider land on the right starting dose rather than guessing.

3

Send the prescription

Your provider sends us the prescription electronically, by fax, or by phone. If you're transferring an existing HRT prescription, we handle the calls to your old pharmacy. New compounded prescriptions are typically ready in 24-48 hours.

4

Pick up or have it delivered

Pick up at any of our three locations, or have it delivered to your door if you're in our local delivery area. For ongoing HRT, we set up medication synchronization so all your refills come on one day each month — and the delivery follows automatically.

Common Questions

HRT questions, answered.

The questions we hear most from patients starting, transferring, or considering compounded hormone replacement therapy.

Do I need a prescription for compounded HRT?
Yes. Hormone replacement therapy — compounded or not — requires a prescription from a licensed provider. We don't prescribe HRT ourselves; we fill prescriptions written by your physician, nurse practitioner, or other prescribing provider. If you don't have a provider yet, talk with your primary care doctor or look for a provider who specializes in hormone health (many functional medicine practitioners, gynecologists, and urologists handle HRT).
How is compounded HRT different from what I would get at a chain pharmacy?
Manufactured HRT comes in fixed doses and fixed combinations — typically capsules, patches, or pre-filled syringes at standard strengths. Compounded HRT lets your provider write a prescription for exactly the dose, ratio, and delivery method that fits you. If you need 0.625mg estradiol when the manufactured option only comes in 0.5mg and 1mg, compounding gets you there. If you need progesterone in a transdermal cream rather than a capsule because of how your body absorbs it, compounding makes that possible. Most chain pharmacies don't compound HRT in-house and would refer those prescriptions out to a compounding pharmacy anyway.
Does insurance cover compounded HRT?
Coverage varies considerably by insurance plan. Many commercial plans cover compounded HRT, but some require prior authorization, some exclude compounded medications entirely, and some only cover specific hormones. Medicare Part D generally does not cover compounded medications. We'll run your prescription through your insurance and let you know what's covered and what your out-of-pocket cost will be. Compounded HRT is typically eligible for HSA and FSA spending.
How long does it take to fill a new HRT prescription?
For new HRT prescriptions, plan on 24 to 48 hours from when we receive your script. Compounded medications are made to order — we don't pull them from a shelf — so each preparation involves measuring, mixing, and quality-checking by our pharmacist. Refills of stable, ongoing prescriptions can sometimes be faster if we have the formulation already saved in your file. Call our Defiance location if you need a rush — we'll tell you honestly whether the timing works.
Can I have my HRT delivered?
Yes, throughout most of Northwest Ohio and several Northeast Indiana communities. Our three locations — Defiance, Paulding, and Continental — each run their own local delivery routes. For patients outside our delivery zone, we ship HRT preparations using temperature-controlled shipping when needed. Some hormone preparations are temperature-sensitive, so we'll discuss the right approach when you set up your prescription.
I'm new to HRT — do you have providers in the area you'd recommend?
We work with a range of providers in the area who prescribe HRT — primary care physicians, OB/GYNs, urologists, and functional medicine practitioners. Call our Defiance location and we can suggest a few options based on where you live and what kind of provider relationship you're looking for. We don't get any compensation for referrals — these are just providers we've worked with consistently and who treat their HRT patients well.
Do you carry manufactured HRT too, or only compounded?
Both. If your prescription is for a manufactured product — Estrace, Climara, AndroGel, Estradot, and others — we'll fill it like any other prescription. Compounded HRT is for situations where the manufactured options don't fit: custom doses, unusual ratios, combination preparations, or delivery methods that don't exist in mass production. Many of our HRT patients use a mix of both, and we coordinate the whole regimen from one pharmacy.
Can men get HRT from Okuley's?
Yes. Testosterone replacement therapy (TRT) for men is one of the most common HRT prescriptions we compound. We work with men's health and primary care providers across the region for both injectable testosterone and transdermal preparations. For more on the men's side specifically — including TRT delivery methods, anastrozole, HCG, and combination protocols — see our men's health page.

Already have a prescription?

Transfer your HRT to a pharmacist who'll know you.

Whether you're new to HRT and just got your first prescription, or you've been on the same regimen for years and want a pharmacy that handles compounded preparations in-house — we'd like to help. Call us, or send us the prescription details through our transfer form.

Compounded at our Defiance location, available at all three stores